I'm running Logic and Protools. I started with this setup years ago because it was sonically and performance wise the best game in town. That is no longer true. Proptools' latency and overall "stability", (DSP and TDM plug-ins) is the best but for the inflated $$$, it ain't floating my boat.
If your clients want Protools you may have to cave and go that route as I've had to but I'm also running an RME hammerfall card along side the Protools stuff for more i/o and it's bullet proof and sounds just as good. Mind you, I'm running an old 24 bit Protools system and have not yet compared it to the HD system but I'm not lining up to pay 18 large for the privilege.
As for the Le system and Mbox, I dunno, buut I think it looks pretty skimpy.